OUR SECRETS

A 2025 study by Gao et al., published in the Journal of Cosmetic Dermatology, demonstrated that hydrogel-based therapies significantly enhance collagen remodeling and hydration in photoaged skin (PMID 40515408). Inspired by this research, PEARLITONE™ integrates an advanced hydrogel delivery system designed to maintain continuous moisture and visibly improve elasticity without invasive procedures. Central to this formulation is acetyl hexapeptide-8, known as the “expression line peptide,” blended with complementary peptides to deliver a refined smoothing effect. Unlike standard formulations that rely on a single active, PEARLITONE™ synergistic peptide complex softens the look of expression lines while preserving the skin’s natural vitality and movement — achieving a balanced, youthful appearance that feels as authentic as it looks.

​

Gao, Q., Xu, C., Tan, M., Wang, Y., Liu, Y., Wang, Y., Fan, Y., Tao, X., Lu, W., Huang, Y., & Teng, Y. (2025). Hydrogel-based therapies for photoaging: Current advances and future perspectives. Journal of Cosmetic Dermatology, 24(6), e70295. https://doi.org/10.1111/jocd.70295​

In the Journal of Cosmetic Dermatology (2024), Yi et al. defined skin boosters as formulations that deliver active hydration into the dermis rather than acting only on the surface (PMID 38481069). This scientific understanding mirrors PEARLITONE™'s bio-delivery system, engineered to penetrate deeply for enhanced hydration, refined texture, and results comparable to professional treatments. Central to this innovation is bakuchiol, a modern botanical alternative to retinol that delivers visible rejuvenation with a gentler, more luxurious experience. Stabilized for consistent overnight performance, it helps skin appear smoother, more even, and renewed without the irritation commonly linked to traditional retinoids. Complementing this effect is a bioavailable mineral complex featuring stabilized copper gluconate, selected for its ability to promote firmness, balance, and a uniform complexion. Through precise sourcing and meticulous formulation, PEARLITONE™ achieves clinical-level performance with an elegance that defines true modern skincare luxury.

​

Yi, K.-H., Lee, Y., Kim, J. Y., & Lee, J. H. (2024). Skin boosters: Definitions and varied classifications. Journal of Cosmetic Dermatology, 23(3), 684–692. https://doi.org/10.1111/jocd.16142​

In Dermatologic Therapy (2022), Bravo et al. demonstrated that optimized topical hyaluronic acid formulations enhance elasticity and tone when paired with biocompatible carriers (PMID 36200921). Building on this foundation, PEARLITONE™’s dual-weight hyaluronic acid complex delivers deep, multi-layer hydration — saturating both the epidermis and the underlying matrix for enduring suppleness and radiance. This scientific precision is elevated with plant-derived squalane, a bioidentical lipid revered for its ability to provide lasting moisture in a weightless, non-greasy texture. More stable than natural squalene, it resists oxidation to preserve its moisturizing and antioxidant power over time, leaving the skin soft, resilient, and luminous. Complementing this is panthenol (pro-vitamin B5), which transforms within the skin to reinforce the barrier, stimulate renewal, and maintain optimal moisture balance. Clinically supported for its soothing and reparative properties, panthenol enhances comfort and glow, completing a formula that embodies both scientific integrity and sensorial luxury.

​

Bravo, B., Correia, P., Gonçalves, J. E., Sant’Anna, B., & Kerob, D. (2022). Benefits of topical hyaluronic acid for skin quality and signs of aging: From literature review to clinical evidence. Dermatologic Therapy, 35(11), e15960. https://doi.org/10.1111/dth.15960​

A comprehensive 2024 review by Hamie et al. in the Journal of Cosmetic Dermatology evaluated common eye-cream ingredients and found that only a limited number demonstrate consistent clinical efficacy (PMID 38873621). Guided by this evidence, PEARLITONE™ eye treatments combine clinically validated niacinamide with precision-encapsulated peptides to visibly smooth, brighten, and rejuvenate the delicate periorbital area. Complementing this advanced formulation is pomegranate seed oil — a rare, cold-pressed extract revered for its concentration of omega-5 fatty acids and powerful antioxidants. Unlike heavier plant oils, it absorbs effortlessly, leaving a refined, luminous finish while deeply nourishing and conditioning the skin. This synergy of bioactive science and sensorial refinement ensures that the eye area appears rested, polished, and illuminated with lasting radiance.

​

​Hamie, H., Kassir, M., Salameh, F., El Hachem, J., Bou Zeid, R., Nassar, D., & Kurban, M. (2024). A review of the efficacy of popular eye cream ingredients. Journal of Cosmetic Dermatology, 23(2), 420–431. https://doi.org/10.1111/jocd.16312​

Research by Pintea et al. in Antioxidants (2025) revealed that specific bioactive peptides play a vital role in preventing oxidative damage and stimulating cellular repair mechanisms (PMID 39858482), forming the scientific foundation of PEARLITONE™ advanced peptide technology. Infused with olive-derived squalane — a luxuriously light, biomimetic emollient prized for its exceptional skin affinity — each formulation envelops the complexion in a weightless veil of hydration that absorbs instantly, leaving only supple radiance. Working in concert with bioactive complexes, this refined blend supports overnight renewal, ensuring skin awakens visibly firmer, deeply nourished, and illuminated with a calm, enduring glow.

​

Pintea, A., Pop, R., Moldovan, R., Stan, R. L., Buzatu, R., Niță, C., & Socaciu, C. (2025). Peptides: Emerging candidates for the prevention and treatment of skin aging. Antioxidants, 14(4), 706. https://doi.org/10.3390/antiox14040706​

In Dermatology (2021), Imhof and Leuthard conducted a systematic review analyzing the efficacy of over-the-counter anti-aging agents and found that many products on the market lack substantiated evidence for long-term results (PMID 32882685). Pearli Tone was created in direct response to this gap, ensuring that every formulation is anchored in independent scientific validation rather than anecdotal claims. At the heart of this commitment is palmitoyl pentapeptide, a next-generation signal peptide renowned for its precision and performance. Engineered with a lipid-linked structure for superior delivery and absorption, it penetrates beyond the surface to visibly refine texture, smooth fine lines, and promote firmer, more resilient skin. This fusion of advanced peptide technology and elevated formulation design reflects PEARLITONE™'s pursuit of scientifically grounded luxury — where innovation meets enduring beauty.​

​

6. Imhof, L., & Leuthard, D. (2021). Topical over-the-counter antiaging agents: An update and systematic review. Dermatology, 237(2), 217–229. https://doi.org/10.1159/000509296